María L. Villamonte Roman

Spread hepatic tumours are not suitable for treatment either by surgery or conventional ablation methods. We propose a novel technique based on irreversible electroporation that could simultaneously treat all liver nodules without affecting healthy tissue. The proposed technique requires decreasing the electrical conductivity of the tumor by injecting a solution through a hepatic artery. In an animal model of liver tumor by implantation of VX2 tumor fragments a solution will be infused through a hepatic artery. Conductivity changes in healthy and tumor liver tissue will be monitored. The period in which the hepatic conductivity is higher than that of the tumor will be defined as the therapeutic window and will be when irreversible transhepatic electroporation will be performed. The animals will be monitored for one month of follow-up. The animals will be sacrificed and selective samples will be used for histological analysis.
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