Eva María Pueyo Périz

To date, no pancreatic stump closure technique has been shown to be superior to any other in distal pancreatectomy. Although several studies have shown a trend towards better results in transection using a radiofrequency device (RFT), no randomized trial for this purpose has been performed to date. Therefore, we designed a randomized clinical trial (RCT), with the hypothesis that this technique used in distal pancreatectomies is superior in reducing clinically relevant pancreatic fistula (CR-POPF) than mechanical closures. TRANSPAIRE is a multicenter randomized controlled trial conducted in 7 Spanish pancreatic centers that includes 112 patients undergoing elective distal pancreatectomy for any indication who will be randomly assigned to RFT or classic stapler transections (control group) in a ratio of 1: 1. The primary outcome is the CR-POPF percentage. aSecondary outcomes include postoperative results, complications, radiological evaluation of the pancreatic stump, metabolomic profile of postoperative peritoneal fluid, survival, and quality of life. Follow-ups will be carried out in the External Consultation at 1, 6 and 12 months postoperatively.
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